Document Detail

Distal myasthenia gravis frequency and clinical course in a large prospective series.
MedLine Citation:
PMID:  12911465     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In Myasthenia gravis (MG) proximal limb, ocular and/or bulbar muscles are most commonly affected, whereas distal extremity muscles are typically spared. The aim of the current study was to assess the frequency of primarily distal MG in the Tyrol and to describe its clinical peculiarities. MATERIAL AND METHODS: Over the past 20 years 84 patients with MG have undergone follow-up at the Department of Neurology of Innsbruck University. Types of presentation, clinical course and treatment response were followed over a period of 20 years (1980-2000). RESULTS: Six of 84 MG patients showed a predominance of muscle weakness and fatigability in distal limb muscles (two at presentation, four over the later course of the illness). There was no difference between distal MG and MG with a more typical distribution of muscle weakness regarding age, gender and response to therapy. CONCLUSIONS: The case series indicates that predominantly distal presentations of otherwise typical MG are more frequent than generally assumed and should be considered in the differential diagnosis of diseases with distal limb weakness.
P Werner; S Kiechl; W Löscher; W Poewe; J Willeit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  108     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2003-10-23     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  209-11     Citation Subset:  IM    
Department of Neurology, Innsbruck University, Innsbruck, Austria.
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MeSH Terms
Extremities / physiopathology*
Middle Aged
Muscle Weakness / physiopathology
Muscle, Skeletal / physiopathology*
Myasthenia Gravis / diagnosis,  physiopathology*
Prospective Studies
Comment In:
Acta Neurol Scand. 2004 Oct;110(4):270; author reply 271-2   [PMID:  15355493 ]

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