| Distal flow determinants in canine myocardium perfused through internal thoracic artery bypass grafts. | |
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MedLine Citation:
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PMID: 7695405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dynamic reactivity and the acute, recruitable flow capacity of an internal thoracic artery (ITA) graft remains unclear. These experiments were conducted in 20 anesthetized dogs with the left ITA grafted to the circumflex artery, off pump, using a brief local occlusion. The left main coronary artery was occluded, rendering the entire left ventricle, including anterior descending artery and circumflex regions, totally dependent on the ITA graft. When the left main coronary artery was occluded, the ITA flow immediately increased more than fivefold (93.4 +/- 9.6 mL/min; mean +/- standard deviation), representing an absolute flow value three times higher than ITA flow measured in situ on the chest wall (27.5 +/- 9.6 mL/min; p < 0.05 versus control), and the ITA graft provided total resting flow requirements (93.4 +/- 9.6 mL/min) for both left anterior descending and circumflex coronary artery perfusion territories at levels comparable with measured native flow values (y = (0.9555)x + 21.9272; r = 0.976; p < 0.05). Pharmacologic challenge with adenosine (0.2 mg.kg-1.min-1 intravenously) significantly increased the graft flow (120.3 +/- 18.7 mL/min; p < 0.05 versus control), but also significantly decreased the mean arterial pressure (85.4 +/- 5.0 versus 74.6 +/- 6.1 mm Hg; p < 0.05). Phenylephrine (0.003 mg.kg-1.min-1 intravenously) significantly decreased ITA graft flow (81.2 +/- 9.0 mL/min; p < 0.05 versus control) despite significantly increased perfusion pressure (84.8 +/- 6.3 versus 108.2 +/- 8.6 mm Hg; p < 0.05 versus control).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M Otaki; R M Lust; Y S Sun; T O Norton; W R Chitwood |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 59 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-04-24 Completed Date: 1995-04-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 829-34 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Anastomosis, Surgical / methods Animals Coronary Circulation / drug effects, physiology* Coronary Vessels / physiology*, surgery Dogs Ligation Phenylephrine / pharmacology Thoracic Arteries / physiology*, transplantation* Vascular Patency Vascular Resistance / drug effects Vasoconstriction / drug effects Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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58-61-7/Adenosine; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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