Document Detail

Distal deep venous thrombosis in a hemophilia A patient with inhibitor and severe infectious disease, 18 days after recombinant activated factor VII transfusion.
MedLine Citation:
PMID:  12032404     Owner:  NLM     Status:  MEDLINE    
We describe a 38 year old hemophilia A patient with a factor VIII inhibitor who was admitted to our Hematology Department in January 2001 with a seriously infected and bleeding perianal ulcer. To treat infection and bleeding the patient received broad spectrum antibiotics and recombinant activated factor VII (rFVIIa) (Novoseven(R)) for about 1 month (see detailed time of administration and dosing schedule of rFVIIa further in text). Eighteen days after his last rVIIa infusion the patient developed an ultrasound proven right calf vein thrombosis. In the whole period of admission, preceding the thrombotic event the patient biologically showed a picture of severe systemic inflammatory disease as indicated by persistent increased levels of D-dimer and fibrinogen (table). It is an interesting point of discussion whether the calf thrombosis was provoked as a consequence of rFVIIa infusion (with symptoms 18 days after the last infusion) or as a consequence of long-standing immobilization and severe inflammatory disease immobilization and severe infection are conditions well known for promoting venous thromboembolic disease.
M G Van der Planken; W Schroyens; F Vertessen; J J Michiels; Z N Berneman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  13     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-28     Completed Date:  2003-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  IM    
Laboratory of Hematology and Hemostasis, Antwerp University Hospital, Edegem, Belgium.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage
Factor VII / administration & dosage,  adverse effects*
Factor VIIa
Hemophilia A / complications*,  drug therapy,  immunology
Immobilization / adverse effects
Infection / complications*,  drug therapy
Isoantibodies / blood
Recombinant Proteins / administration & dosage,  adverse effects*
Venous Thrombosis / etiology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Isoantibodies; 0/Recombinant Proteins; 0/recombinant FVIIa; 9001-25-6/Factor VII; EC VIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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