Document Detail

Dissolution of xylitol from a food supplement administered with a novel slow-release pacifier: preliminary results.
MedLine Citation:
PMID:  17555696     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of the study was to monitor the pattern of release and salivary xylitol concentrations during sucking of a slow-release pacifier used to deliver a novel food supplement. METHODS: The food supplement tablet contained 300 mg xylitol and 0.5 x 10(10) colony-forming units of Bifidobacterium lactis Bb-12 (Bb-12). The reference tablet contained 300 mg xylitol and was used by 10 adults (mean age 32 years) in the study. Whole saliva samples were collected with 2.5 min intervals during pacifier sucking. The salivary xylitol concentrations were determined using an enzyme assay kit. RESULTS: All subjects showed salivary xylitol concentrations exceeding 1% at least at one collection point. The xylitol and xylitol-Bb-12 tablets showed similar dissolving with no clear concentration peaks (comparison of saliva collection times; p = 0.139). CONCLUSION: Xylitol released from the food supplement, delivered with the novel pacifier, may result in salivary xylitol concentrations high enough to inhibit mutans streptococci in vivo.
T Taipale; K Pienihakkinen; P Alanen; J Jokela; E Söderling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry     Volume:  8     ISSN:  1818-6300     ISO Abbreviation:  -     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-08     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101277157     Medline TA:  Eur Arch Paediatr Dent     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  D; IM    
Korpilahti-Muurame Health Care Center; University of Turku, Finland.
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MeSH Terms
Cariostatic Agents / analysis,  pharmacokinetics*
Delayed-Action Preparations
Dietary Supplements*
Drug Carriers
Equipment Design
Probiotics / administration & dosage,  therapeutic use
Saliva / chemistry,  metabolism
Sucking Behavior
Sweetening Agents / analysis,  pharmacokinetics*
Xylitol / analysis,  pharmacokinetics*
Reg. No./Substance:
0/Cariostatic Agents; 0/Delayed-Action Preparations; 0/Drug Carriers; 0/Sweetening Agents; 87-99-0/Xylitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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