Document Detail

Dissolution rates of model gallstones in human and animal biles and importance of interfacial resistance.
MedLine Citation:
PMID:  408477     Owner:  NLM     Status:  MEDLINE    
Cholesterol monohydrate dissolution kinetics in human gallbladder bile were studied to determine the magnitudes of the in vitro dissolution rates, the rate resistances in human gallbladder bile, and the extent that the interfacial resistance is the rate-determining factor. Dissolution rate studies also were conducted using human duodenal bile and animal bile for comparison. The dissolution rate resistance, R, ranged from 10(4) sec/cm for chicken bile to 10(4)-10(6) sec/cm for human bile. Interfacial resistance was the rate-determining factor for essentially all results. Where chemical composition data were obtained, the R values for the human bile samples were consistent with predictions made from the simulated bile studies. In two human gallbladder specimens having low bile acid-lecithin molar ratios (i.e., 2.9 and 2.3), very high R values of 1.9 X 10(5) and 4.1 X 10(5) sec/cm were found. These values were in good agreement with the findings in the simulated bile studies and suggest that stone dissolution in patients with low bile acid-lecithin ratios may proceed very slowly, even when the bile is highly undersaturated with respect to cholesterol.
A M Molokhia; A F Hofmann; W I Higuchi; M Tuchinda; K Feld; S Prakongpan; R G Danzinger
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  66     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1101-5     Citation Subset:  IM    
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MeSH Terms
Bile / analysis,  metabolism*
Cholelithiasis / metabolism*
Duodenum / metabolism
Gallbladder / metabolism
Lipids / analysis
Reg. No./Substance:
0/Lipids; 0/Micelles

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