| Dissolution profile determination of a multicomponent product using a rapid liquid chromatographic analysis. | |
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MedLine Citation:
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PMID: 6737266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A system was developed which is capable of monitoring the dissolution profiles of each of the active components in a two-component combination product. The UV spectra of the two drugs (metoprolol and hydrochlorothiazide) overlap considerably, making conventional UV analysis of either component unrealistic. By resolving the two drugs on a high-performance liquid chromatographic (HPLC) system both can be quantitated after separation. The analysis is sufficiently short to allow for the use of a six-station dissolution tester in tandem with an HPLC for determination of dissolution profiles. The HPLC system and equipment, can monitor six samples of this product at 5-min intervals in real analysis time. |
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Authors:
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R Soltero; J Robinson; D Adair |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 73 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-08-22 Completed Date: 1984-08-22 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 799-803 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Chromatography, High Pressure Liquid / instrumentation, methods Drug Combinations* Hydrochlorothiazide / analysis Metoprolol / analysis Solubility* Spectrophotometry, Ultraviolet / methods |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 37350-58-6/Metoprolol; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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