Document Detail

Dissolution of pancreatic stones by oral trimethadione in patients with chronic calcific pancreatitis.
MedLine Citation:
PMID:  7827299     Owner:  NLM     Status:  MEDLINE    
The effect of oral dissolution therapy for pancreatic stones was evaluated in patients with chronic calcific pancreatitis. The anti-epileptic agent trimethadione was given orally to 30 outpatients at a dose of 0.9-1.5 g daily. On plain X-ray films and CT scans of the abdomen, pancreatic stones began to be dissolved around 8 months of treatment, and diminished in size and number or disappeared in 21 patients (70%) during the mean follow-up period of 32 months. The effect of trimethadione treatment on dissolution of stones was not closely related to the aetiology of the disease, distribution and size of stones, previous history of surgical interventions, or the degree of pancreatic dysfunctions. In three patients who stopped this medication of their own accord, pancreatic stones re-increased or reappeared about 6 months later. During trimethadione treatment, impaired exocrine pancreatic function returned to normal in four of nine patients examined, and diabetes mellitus was well controlled by either diet therapy alone or oral hypoglycaemic agents in eight of 10 patients who did not need insulin before trimethadione treatment. Complete relief of pain was noted in 73% of patients during the treatment. Overall gains and no change in bodyweight were observed in 83% of patients. Mild photophobia was the most common side effect, but could be easily overcome by wearing sunglasses. No severe side effects were observed in the liver, kidney, blood or the eyeground. Pancreatic stones in 30 patients not treated with trimethadione neither disappeared nor diminished spontaneously. Trimethadione treatment may be a useful tool for chemical dissolution of pancreatic stones.
A Noda; M Okuyama; H Murayama; K Takeuchi; T Yokota; T Kobayashi; T Takayama
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Publication Detail:
Type:  Case Reports; Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  9     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  478-85     Citation Subset:  IM    
Third Department of Internal Medicine, Aichi Medical University, Japan.
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MeSH Terms
Administration, Oral
Body Weight / drug effects
Calculi / complications,  drug therapy*,  physiopathology,  radiography
Chronic Disease
Drug Administration Schedule
Middle Aged
Pain / prevention & control
Pancreas / physiopathology
Pancreatitis / complications,  drug therapy*,  physiopathology,  radiography
Treatment Outcome
Trimethadione / administration & dosage*,  adverse effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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