Document Detail


Dissolution of acetylsalicylic acid from acetylsalicylic acid-polyethylene glycol 6000 coprecipitates.
MedLine Citation:
PMID:  1178776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Investigation of possible enhancement of dissolution of acetylsalicylic acid via coprecipitation with polyethylene glycol 6000 was carried out. The results indicated that the initial amount of acetylsalicylic acid released from its coprecipitates or physical mixtures with polyethylene glycol 6000 was increased over that amount released from plain acetylsalicylic acid powder during the same period of time. This was attributed to lowering of the surface tension of the dissolution medium imparted by polyethylene glycol 6000. The effect of particle size of the coprecipitate on the dissolution rate of acetylsalicylic acid was also studied. Greater viscosity values produced by higher concentrations of polyethylene glycol 6000 in the coprecipitates appeared also to influence the dissolution rate of acetylsalicylic acid. The use of optimum concentration of polyethylene glycol 6000 in physical mixtures or coprecipitates would seem advantageous in the preparation of solid dosage forms containing acetylsalicylic acid.
Authors:
A F Asker; C W Whitworth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  30     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1976-01-02     Completed Date:  1976-01-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  530-1     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Pharmaceutic
Aspirin*
Chemical Precipitation
Chemistry, Pharmaceutical
Drug Combinations
Particle Size
Polyethylene Glycols*
Powders
Solubility
Surface Tension
Time Factors
Viscosity
Chemical
Reg. No./Substance:
0/Adjuvants, Pharmaceutic; 0/Drug Combinations; 0/Polyethylene Glycols; 0/Powders; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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