Document Detail

Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity.
MedLine Citation:
PMID:  7569957     Owner:  NLM     Status:  MEDLINE    
Furosemide, a chloride cotransport inhibitor, reversibly blocked synchronized burst discharges in hippocampal slices without reducing the pyramidal cell response to single electrical stimuli. Images of the intrinsic optical signal acquired during these slice experiments indicated that furosemide coincidentally blocked changes in extracellular space. In urethane-anesthetized rats, systemically injected furosemide blocked kainic acid-induced electrical discharges recorded from cortex. These results suggest that (i) neuronal synchronization involved in epileptiform activity can be dissociated from synaptic excitability; (ii) nonsynaptic mechanisms, possibly associated with furosemide-sensitive cell volume regulation, may be critical for synchronization of neuronal activity; and (iii) agents that affect extracellular volume may have clinical utility as antiepileptic drugs.
D W Hochman; S C Baraban; J W Owens; P A Schwartzkroin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  270     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
Department of Neurological Surgery, University of Washington, Seattle 98195, USA.
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MeSH Terms
4-Aminopyridine / pharmacology
Anticonvulsants / pharmacology*
Bicuculline / pharmacology
Electric Stimulation
Entorhinal Cortex / physiology
Extracellular Space / drug effects,  physiology
Furosemide / pharmacology*
Hippocampus / drug effects,  physiology*
Kainic Acid / pharmacology
Magnesium / pharmacology
Membrane Potentials / drug effects
Potassium / pharmacology
Pyramidal Cells / drug effects,  physiology*
Rats, Sprague-Dawley
Status Epilepticus / chemically induced,  physiopathology*
Synaptic Transmission / drug effects
Grant Support
Reg. No./Substance:
0/Anticonvulsants; 485-49-4/Bicuculline; 487-79-6/Kainic Acid; 504-24-5/4-Aminopyridine; 54-31-9/Furosemide; 7439-95-4/Magnesium; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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