Document Detail

Dissociation of responses to extracellular thirst stimuli following zona incerta lesions.
MedLine Citation:
PMID:  353819     Owner:  NLM     Status:  MEDLINE    
In male albino rats, bilateral lesions in the anterior zona incerta which decrease ad lib and food-deprivation water intake and osmotic thirst but leave hypovolemic thirst intact, severely impaired or abolished drinking in response to systemic injections of isoproterenol or central administration of angiotensin II. Water intake following water deprivation was reduced by one-fourth. Reasons for the dissociation of responses to hypovolemia, water deprivation, isoproterenol and angiotensin were suggested.
L L Walsh; S P Grossman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  8     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-15     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / pharmacology
Brain / drug effects,  physiology*
Brain Injuries
Drinking / drug effects*
Isoproterenol / pharmacology*
Stereotaxic Techniques
Thirst / drug effects,  physiology*
Water Deprivation
Reg. No./Substance:
11128-99-7/Angiotensin II; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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