Document Detail


Dissociation between tumour cell cytostatic and immuno-suppressive capacity of human monocytes activated with lymphokines.
MedLine Citation:
PMID:  7080839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activation of monocytes with lymphokines from BCG-stimulated lymphocytes increased the capacity to inhibit DNA-synthesis in a tumour cell line (NHIK 3025) at all stages of monocyte maturation in vitro. However, the capacity of monocytes to suppress DNA-synthesis in mixed lymphocyte cultures (MLC) was reduced, indicating a dissociation of the immuno-suppressive and tumour cell cytostatic functions of lymphokine-activated monocytes. Supernatants of lymphokine-activated monocytes inhibited DNA synthesis in the tumour cell line, but not in MLC. Monocytes from donors with a strong tuberculin reaction produced supernatants with a stronger cytostatic activity than monocytes from donors with a weak tuberculin reaction. By in vitro maturation, even the later monocytes acquired ability to produce supernatants that were strongly inhibitory to tumour cells.
Authors:
G Unsgaard; J Hammerstrøm; J Lamvik
Related Documents :
16751389 - T cell-independent, tlr-induced il-12p70 production in primary human monocytes.
7820219 - Growth hormone (gh) and the immune system: impaired phagocytic function in children wit...
3037549 - Cannabinoids induce incomplete maturation of cultured human leukemia cells.
1685419 - Inhibition of endotoxin-induced monocytic procoagulant activity by n-alcohols and anest...
8123589 - Antisense down-regulation of metallothionein in a human monocytic cell line alters adhe...
16436679 - Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesen...
1338889 - Cd43 is expressed normally on wiskott-aldrich-derived lymphocytes.
2761539 - A growth factor-responsive gene of murine balb/c 3t3 cells encodes a protein homologous...
24699869 - A novel ex vivo isolation and expansion procedure for chimeric antigen receptor engraft...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology     Volume:  90     ISSN:  0108-0202     ISO Abbreviation:  Acta Pathol Microbiol Immunol Scand C     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  8206624     Medline TA:  Acta Pathol Microbiol Immunol Scand C     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Division
Cell Line
Cytotoxicity, Immunologic*
DNA Replication
Humans
Lymphocyte Activation*
Lymphokines / pharmacology*
Monocytes / immunology*
Neoplasms / metabolism*
Time Factors
Chemical
Reg. No./Substance:
0/Lymphokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Technical aspects of rosette tests for the demonstration of lymphocyte subpopulations.
Next Document:  Half-way services in the rehabilitation of chronic mental patients. A residential programme.