Document Detail

Dissociation between tumour cell cytostatic and immuno-suppressive capacity of human monocytes activated with lymphokines.
MedLine Citation:
PMID:  7080839     Owner:  NLM     Status:  MEDLINE    
Activation of monocytes with lymphokines from BCG-stimulated lymphocytes increased the capacity to inhibit DNA-synthesis in a tumour cell line (NHIK 3025) at all stages of monocyte maturation in vitro. However, the capacity of monocytes to suppress DNA-synthesis in mixed lymphocyte cultures (MLC) was reduced, indicating a dissociation of the immuno-suppressive and tumour cell cytostatic functions of lymphokine-activated monocytes. Supernatants of lymphokine-activated monocytes inhibited DNA synthesis in the tumour cell line, but not in MLC. Monocytes from donors with a strong tuberculin reaction produced supernatants with a stronger cytostatic activity than monocytes from donors with a weak tuberculin reaction. By in vitro maturation, even the later monocytes acquired ability to produce supernatants that were strongly inhibitory to tumour cells.
G Unsgaard; J Hammerstrøm; J Lamvik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology     Volume:  90     ISSN:  0108-0202     ISO Abbreviation:  Acta Pathol Microbiol Immunol Scand C     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  8206624     Medline TA:  Acta Pathol Microbiol Immunol Scand C     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
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MeSH Terms
Cell Division
Cell Line
Cytotoxicity, Immunologic*
DNA Replication
Lymphocyte Activation*
Lymphokines / pharmacology*
Monocytes / immunology*
Neoplasms / metabolism*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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