Document Detail

Dissociation between heart rate and sympathetic nerve responses to baroreceptor activation in spontaneously hypertensive rats.
MedLine Citation:
PMID:  2455183     Owner:  NLM     Status:  MEDLINE    
We tested the baroreflex in conscious, stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto controls (WKY) with incremental bolus injections of nitroprusside and methoxamine. The change in heart rate (HR) per change in mean blood pressure (MAP) was greater in WKY than in SHRSP. In contrast, the change in splanchnic nerve activity (SpNA) per change in MAP was greater in SHRSP than in WKY. The sympathetic outflow in SHRSP seems more reactive to blood pressure changes than in WKY. The discordance in HR and SpNA changes suggests that the integration of autonomic function in SHRSP is impaired.
T Unger; G Demmert; P Rohmeiss; R Veelken; F C Luft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S221-4     Citation Subset:  IM    
German Institute for High Blood Pressure Research, Heidelberg, F.R.G.
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MeSH Terms
Blood Pressure
Heart Rate*
Hypertension / drug therapy,  physiopathology*
Methoxamine / pharmacology
Nitroprusside / pharmacology
Pressoreceptors / metabolism*
Rats, Inbred WKY
Splanchnic Nerves / metabolism*
Grant Support
Reg. No./Substance:
15078-28-1/Nitroprusside; 390-28-3/Methoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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