| Dissociation between distortion-product and click-evoked otoacoustic emissions in sheep (Ovis aries). | |
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MedLine Citation:
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PMID: 19206800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distortion-product otoacoustic emissions (DPOAEs) were weak or absent in about one-third of sheep (Ovis aries) of both sexes tested for otoacoustic emissions (OAEs) even though their click-evoked OAEs (CEOAEs) seemingly were typical of other sheep of the same sex. Various pieces of evidence suggest that the absence of measurable DPOAEs was unlikely to be attributable to anesthetic effects, a poorly located probe tip, a pressure differential between middle and outer ears, season of the year, body position during testing, temperature effects, or previous medical history. Sheep apparently can exhibit a marked dissociation between DPOAEs and CEOAEs. In those sheep having measurable DPOAEs, the DPOAEs were stronger in males than in females, which is the opposite direction of effect from the CEOAEs measured in these same sheep and in humans. In female sheep exposed to higher-than-normal levels of androgens during gestation, the measurable DPOAEs were stronger than in untreated females. Although this also was the opposite direction of effect from expected, it still was a shift in the male direction, in accord with past findings about the masculinizing effects of androgens on OAEs. In sheep, androgen exposure appears to have different effects on the mechanisms underlying DPOAEs from those underlying CEOAEs. |
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Authors:
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Dennis McFadden; Edward G Pasanen; Michelle D Valero; Eila K Roberts; Theresa M Lee |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 124 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-02-11 Completed Date: 2009-04-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 3730-8 Citation Subset: IM |
Affiliation:
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Department of Psychology and Center for Perceptual Systems, University of Texas, Austin, Texas 78712-0187, USA. mcfadden@psy.utexas.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Androgens / pharmacology Animals Dihydrotestosterone / pharmacology Ear Canal / drug effects, physiology* Estradiol / pharmacology Female Male Orchiectomy Otoacoustic Emissions, Spontaneous* / drug effects Ovariectomy Pregnancy Prenatal Exposure Delayed Effects Sex Factors Sheep Testosterone / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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DC00153/DC/NIDCD NIH HHS; HD44232/HD/NICHD NIH HHS; R01 DC000153-29/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 50-28-2/Estradiol; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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