| Dissociation between corticotrophin and catecholamine responses to isoprenaline in humans. | |
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MedLine Citation:
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PMID: 2822312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The pituitary-adrenocortical, sympathoadrenomedullary and renin-angiotensin-aldosterone systems contribute to circulatory and metabolic homeostasis during stress. One possible site of co-ordination of these systems is the beta-adrenoceptor. 2. To determine whether circulating beta-adrenoceptor agonists can act hormonally to stimulate these systems simultaneously, plasma concentrations of corticotrophin (ACTH), noradrenaline, adrenaline and plasma renin activity were measured during graded intravenous infusions of isoprenaline in 20 people. 3. Administration of isoprenaline caused dose-related increases in noradrenaline (94% at the highest dose) and renin activity (189%), but decreases in ACTH (25%) and adrenaline (20%), findings inconsistent with simultaneous activation of these systems by circulating beta-adrenoceptor agonists. |
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Authors:
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G Eisenhofer; D S Goldstein; R W Stull; P W Gold; H R Keiser; I J Kopin |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 14 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-11-25 Completed Date: 1987-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 337-41 Citation Subset: IM |
Affiliation:
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Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood* Adult Dose-Response Relationship, Drug Epinephrine / blood* Female Humans Infusions, Intravenous Isoproterenol / blood, pharmacology* Male Norepinephrine / blood* Renin / blood* Sympathetic Nervous System / drug effects |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7683-59-2/Isoproterenol; 9002-60-2/Adrenocorticotropic Hormone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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