| Dissociation between cortical activation and cognitive performance under pharmacological blood pressure elevation in chronic hypotension. | |
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MedLine Citation:
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PMID: 17481800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study explored the impact of pharmacological blood pressure elevation on cortical activation and reaction time in chronic hypotension. Effects of the sympathomimetic etilefrine were investigated in 50 hypotensive persons based on a randomized, placebo-controlled double blind design. As an indicator of cortical excitability, the contingent negative variation (CNV), induced by a constant foreperiod reaction time task, was assessed at frontal (F3, Fz, F4) and central (C3, Cz, C4) scalp sites. Etilefrine provoked a decrease in the frontal and central CNV. In contrast, shorter reaction times were observed following drug administration. The degree of pharmacologically induced blood pressure elevation was correlated to CNV attrition as well as to performance enhancement. Inhibitory effects of baroreceptor activation on cortical excitability and enhanced cerebral blood flow are considered to be involved in mediating the effects of blood pressure elevation on cerebral functioning. Implications for the treatment of chronic hypotension are discussed. |
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Authors:
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Stefan Duschek; Miriam Hadjamu; Rainer Schandry |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-04-05 |
Journal Detail:
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Title: Biological psychology Volume: 75 ISSN: 0301-0511 ISO Abbreviation: Biol Psychol Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2007-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375566 Medline TA: Biol Psychol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 277-85 Citation Subset: IM |
Affiliation:
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University of Munich, Germany. duschek@psy.uni-muenchen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arousal / drug effects, physiology Cerebral Cortex / blood supply, drug effects*, physiopathology Cognition / drug effects*, physiology Contingent Negative Variation / drug effects, physiology Double-Blind Method Electroencephalography / drug effects* Etilefrine / therapeutic use* Female Humans Hypotension / drug therapy*, physiopathology Male Pressoreceptors / drug effects, physiopathology Psychomotor Performance / drug effects, physiology Reaction Time / drug effects, physiology Regional Blood Flow / drug effects, physiology Sympathomimetics / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Sympathomimetics; 709-55-7/Etilefrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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