| Dissociation between clinical and exercise responsiveness to beta-blockade in angina. | |
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MedLine Citation:
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PMID: 32144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty outpatients with mild angina were prescribed placebo tablets b.i.d. for 7 weeks followed by acebutolol, a cardioselective beta-blocker, 200 mg b.i.d. for 21 weeks under single-blind conditions. One graded multistage treadmill test was carried out after each treatment period and an angina diary was filled daily for the 6 months of the trial. Attack frequency declined by 71% from 2.59 per week on placebo to 0.76 per week on acebutolol (p less than 0.05). Exercise duration on the treadmill increased by 56%, from 5.95 minutes on placebo to 9.32 minutes on acebutolol (p less than 0.001). A satisfactory clinical response (50% or greater decline in attack frequency per week) occurred in 15 out of 19 patients (79%; a 100% or greater increase in exercise duration on the treadmill was observed in 10 out of 19 cases (53%). Exercise responsiveness was well predicted by exercise duration on placebo (r = 0.91, p less than 0.0005), patients with the least initial tolerance being the most improved. Clinical responsiveness was not well predicted by initial exercise tolerance (r = 0.38, N;S.) or by the improvement in exercise tolerance (r = 0.33, N.S.). It is concluded that acebutolol substantially reduces anginal attack frequency even in patients in whom exercise tolerance is not significantly improved, at the dose of 400 mg/day. |
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Authors:
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G Tremblay; P Biron; A Proulx |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology and biopharmacy Volume: 16 ISSN: 0340-0026 ISO Abbreviation: Int J Clin Pharmacol Biopharm Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7505527 Medline TA: Int J Clin Pharmacol Biopharm Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 508-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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adverse effects,
pharmacology,
therapeutic use Adrenergic beta-Antagonists / pharmacology* Adult Aged Angina Pectoris / drug therapy, physiopathology* Exercise Test Female Humans Male Middle Aged Physical Exertion* Placebos |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Placebos; 37517-30-9/Acebutolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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