Document Detail

Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.
MedLine Citation:
PMID:  10883798     Owner:  NLM     Status:  MEDLINE    
The administration of the dopamine antagonists, pimozide and alpha-flupenthixol, to rats reduced Pavlovian-instrumental transfer when a conditioned stimulus (CS) that had been paired with a noncontingent food reward was tested on instrumental performance. The administration of the antagonists during Pavlovian conditioning and/or testing abolished the enhancement of instrumental performance by the CS. The effect of both antagonists on instrumental incentive learning was then examined. After training in which the rats performed 2 responses for different food rewards, they consumed 1 type food under the antagonists and the other type under vehicle during reexposure. When instrumental responding was subsequently tested in extinction, performance was unaffected by whether the rats had been reexposed to the training reward under the antagonists. These results suggest that Pavlovian and instrumental incentive learning are not mediated by a common process.
A Dickinson; J Smith; J Mirenowicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  114     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-11-20     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-83     Citation Subset:  IM    
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MeSH Terms
Appetitive Behavior / drug effects
Association Learning / drug effects
Conditioning, Classical / drug effects*
Conditioning, Operant / drug effects*
Dopamine Antagonists / pharmacology*
Dose-Response Relationship, Drug
Flupenthixol / pharmacology*
Pimozide / pharmacology*
Rats, Inbred Strains
Transfer (Psychology)
Reg. No./Substance:
0/Dopamine Antagonists; 1HIZ4DL86F/Pimozide; FA0UYH6QUO/Flupenthixol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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