Document Detail


Dissociation of 68,000 Mr heat shock protein synthesis from thermotolerance expression in rat fibroblasts.
MedLine Citation:
PMID:  6463215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rat embryonic fibroblasts growing exponentially at either 35, 37, or 39 degrees C were exposed to 42 degrees C for times up to 6 hr. Cell survival was unaffected by this heat shock in cultures growing at 39 degrees C but survival was decreased in a temperature dependent manner in cells growing at 37 or 35 degrees C. Exposure to 42 degrees C of cells previously adapted to 35 or 37 degrees C resulted in the induction of heat shock proteins (hsps) with apparent molecular weights of 68,000 (hsp 68), 70,000 (hsp 70), and 89,000 (hsp 89); cells previously adapted to 39 degrees C expressed all hsps except hsp 68. Inasmuch as the synthesis of certain hsps may function to protect cells from thermal damage, these data indicate that hsp 68 may not be required for this adaptation-related thermotolerant survival response. Hsp 68 may only be expressed in cells destined to die.
Authors:
R B Widelitz; B E Magun; E W Gerner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation research     Volume:  99     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-06     Completed Date:  1984-09-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-7     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Acclimatization*
Animals
Cell Survival*
Fibroblasts / metabolism
Heat-Shock Proteins / biosynthesis*
Hot Temperature*
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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