| Dissociation of 68,000 Mr heat shock protein synthesis from thermotolerance expression in rat fibroblasts. | |
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MedLine Citation:
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PMID: 6463215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat embryonic fibroblasts growing exponentially at either 35, 37, or 39 degrees C were exposed to 42 degrees C for times up to 6 hr. Cell survival was unaffected by this heat shock in cultures growing at 39 degrees C but survival was decreased in a temperature dependent manner in cells growing at 37 or 35 degrees C. Exposure to 42 degrees C of cells previously adapted to 35 or 37 degrees C resulted in the induction of heat shock proteins (hsps) with apparent molecular weights of 68,000 (hsp 68), 70,000 (hsp 70), and 89,000 (hsp 89); cells previously adapted to 39 degrees C expressed all hsps except hsp 68. Inasmuch as the synthesis of certain hsps may function to protect cells from thermal damage, these data indicate that hsp 68 may not be required for this adaptation-related thermotolerant survival response. Hsp 68 may only be expressed in cells destined to die. |
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Authors:
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R B Widelitz; B E Magun; E W Gerner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiation research Volume: 99 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-09-06 Completed Date: 1984-09-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-7 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Animals Cell Survival* Fibroblasts / metabolism Heat-Shock Proteins / biosynthesis* Hot Temperature* Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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