| Dissociated behavior of low-frequency responses and high-frequency oscillations after systemic morphine administration in conscious rats. | |
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MedLine Citation:
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PMID: 19934783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been proposed that high-frequency oscillations (HFOs) and underlying conventional somatosensory-evoked potentials (SEPs) have different brain origins. To further explore the neural mechanism of HFOs, we recorded the SEPs responding to high-intensity electrical stimulation applied to the hind paw of conscious, freely moving rats. We also investigated the effect of systemic morphine on HFOs and the conventional SEPs. HFOs after high-intensity electrical stimulation showed a widespread distribution in frontal and temporal regions of the brain. The amplitude of HFOs was significantly decreased by systemic morphine, whereas the primary conventional SEP components remained unaffected. The different changes in HFOs and primary SEP components after systemic morphine administration provided further evidence for the hypothesis that HFOs and underlying conventional SEP components have different origins. |
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Authors:
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Guo-Liang Li; Zhi-Mei Qiao; Ji-Sheng Han; Fei Luo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 21 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 2-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biophysical Phenomena / drug effects*, physiology Brain Mapping Cerebral Cortex / drug effects*, physiology Consciousness / physiology Electric Stimulation / adverse effects, methods Electroencephalography Evoked Potentials, Somatosensory / drug effects*, physiology Male Morphine / administration & dosage, pharmacology* Narcotics / administration & dosage, pharmacology* Pain Threshold / drug effects, physiology Rats Rats, Sprague-Dawley Reaction Time / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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