Document Detail

Dissimilarity between seasonal changes in airway responsiveness to adenosine-5'-monophosphate and methacholine in patients with grass pollen allergic rhinitis: relation to induced sputum.
MedLine Citation:
PMID:  14555861     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In patients with allergic rhinitis, bronchial hyperresponsiveness (BHR) and airway inflammation may increase during pollen exposure. BHR can be assessed by adenosine-5'-monophosphate (AMP) or methacholine challenge. It has been suggested that BHR to AMP is more closely related to airway inflammation than BHR to methacholine. Seasonal allergic rhinitis offers a dynamic model to study changes in BHR and airway inflammation during natural allergen exposure. METHODS: We measured BHR [provocative concentration causing a 20% fall (PC(20)) in forced expiratory volume in 1 s (FEV(1))] to AMP and methacholine, and induced sputum cells in 16 rhinitis patients before and during the 2001 grass pollen season. RESULTS: There was a decrease in PC(20) methacholine during pollen exposure (geometric mean PC(20) from 3.22 to 1.73 mg/ml, p = 0.0023), whereas no reduction was observed for PC(20) AMP (p = 0.11). There was no increase in sputum eosinophils [pre: 0.69% (95% confidence interval 0.22-2.07); during: 1.85 (0.55- 5.6), p = 0.31]. Although the correlation of log PC(20) methacholine and log PC(20) AMP at baseline was good (r = 0.76, p = 0.001), individual seasonal changes (doubling concentrations) in PC(20) methacholine were not correlated with changes in PC(20) AMP (rho = 0.21, p = 0.44). There was no correlation between baseline log PC(20) methacholine or seasonal changes in PC(20) methacholine and sputum eosinophils (p > 0.12, all correlations). In contrast, there was a significant correlation between seasonal changes in PC(20) AMP and changes in sputum eosinophils (rho = -0.59, p = 0.025). CONCLUSIONS: These data show dissimilarity between seasonal changes in PC(20) AMP and methacholine in patients with seasonal allergic rhinitis. Moreover, PC(20) AMP seems to be more closely related to sputum eosinophils than PC(20) methacholine. The clinical significance of this discrepancy is unclear.
Jutta Beier; Kai Michael Beeh; Oliver Kornmann; Emila Morankic; Nicole Ritter; Roland Buhl
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  132     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-13     Completed Date:  2003-11-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  76-81     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany.
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MeSH Terms
Adenosine Monophosphate / pharmacology*
Bronchial Hyperreactivity / blood,  immunology*
Bronchoconstrictor Agents / pharmacology*
Cell Count
Eosinophils / immunology
Forced Expiratory Volume / immunology
Methacholine Chloride / pharmacology*
Middle Aged
Poaceae / immunology
Pollen / immunology*
Rhinitis, Allergic, Seasonal / blood,  immunology*
Sputum / cytology*,  drug effects
Statistics, Nonparametric
Reg. No./Substance:
0/Bronchoconstrictor Agents; 61-19-8/Adenosine Monophosphate; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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