Document Detail

Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro.
MedLine Citation:
PMID:  12925584     Owner:  NLM     Status:  MEDLINE    
During development neural crest cells give rise to a wide variety of specialized cell types in response to cytokines from surrounding tissues. Depending on the cranial-caudal level of their origin, different populations of neural crest cells exhibit differential competence to respond to these signals as exemplified by the unique ability of cranial neural crest to form skeletal cell types. We show that in addition to differences in whether they respond to particular signals, cranial neural crest cells differ dramatically from the trunk neural crest cells in how they respond to specific extracellular signals, such that under identical conditions the same signal induces dissimilar cell fate decisions in the two populations in vitro. Conversely, the same differentiated cell types are induced by different signals in the two populations. These in vitro differences in neural crest response are consistent with in vivo manipulations. We also provide evidence that these differences in responsiveness are modulated, at least in part, by differential expression of Hox genes within the neural crest.
Arhat Abzhanov; Eldad Tzahor; Andrew B Lassar; Clifford J Tabin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  130     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-08-19     Completed Date:  2003-12-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  4567-79     Citation Subset:  IM    
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Body Patterning
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins / metabolism
Cell Differentiation / physiology*
Cell Survival
Cells, Cultured
Chick Embryo
Chondrogenesis / physiology
Cytoskeletal Proteins / metabolism
Fibroblast Growth Factor 2 / metabolism
Homeodomain Proteins / genetics
In Situ Hybridization
Mesencephalon / cytology,  growth & development*
Morphogenesis / physiology*
Neural Crest / cytology*,  physiology
Neurons / cytology,  metabolism
Rhombencephalon / cytology,  growth & development
Trans-Activators / metabolism
Transforming Growth Factor beta / metabolism
Transforming Growth Factor beta1
beta Catenin
Grant Support
Reg. No./Substance:
0/Bone Morphogenetic Protein 2; 0/Bone Morphogenetic Proteins; 0/Cytoskeletal Proteins; 0/Homeodomain Proteins; 0/Trans-Activators; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 0/beta Catenin; 103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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