| Disseminated tuberculoid lesions in infants following BCG vaccination. | |
| | |
MedLine Citation:
|
PMID: 6749273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The records of 830 consecutive autopsies at Children's Hospital, Winnipeg revealed that 26 of the 36 infants (34 Canadian Indian, 1 Inuit and 1 Caucasian) given BCG vaccine shortly after birth had tuberculoid granulomas in various sites, including the vaccination site, regional lymph nodes, liver, spleen, lung, bone marrow and salivary gland. Mycobacterium bovis, BCG type, was identified in three of the four cases in which isolation was attempted. The principal causes of death had been sudden infant death syndrome and respiratory tract infections. None of the infants had histologic evidence of an immune deficiency. However, it is possible that in two cases the dissemination of BCG was enhanced by a temporary immunologic defect induced by malnutrition. |
| | |
Authors:
|
C L Trevenen; R D Pagtakhan |
Related Documents
:
|
16289943 - Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and conc... 2796813 - Sudden infant death syndrome and environmental temperature: further evidence for a time... 19180633 - Comparative study of clinical characteristics of amniotic rupture sequence with and wit... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Canadian Medical Association journal Volume: 127 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1982 Sep |
Date Detail:
|
Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
|
Languages: eng Pagination: 502-4 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
BCG Vaccine
/
adverse effects* Humans Infant Liver / pathology Manitoba Mycobacterium bovis / isolation & purification Tuberculoma / pathology* Tuberculosis / immunology, prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/BCG Vaccine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The latex agglutination test versus counterimmunoelectrophoresis for rapid diagnosis of bacterial me...
Next Document: The use and potential of bone marrow allograft and whole-body irradiation in the treatment of leukem...