Document Detail

Disseminated subcutaneous nocardiosis caused by Nocardia farcinica diagnosed by FNA biopsy and 16S ribosomal gene sequencing.
MedLine Citation:
PMID:  18335548     Owner:  NLM     Status:  MEDLINE    
Nocardia is an infrequent but significant cause of infections in the immunocompromised host. Clinical syndromes are varied and ranges from pulmonary, disseminated, cutaneous, and CNS involvement. Here we describe a case of disseminated subcutaneous nodules in a patient with multiple myeloma caused by Nocardia farcinica. The diagnosis was made by FNA biopsy which revealed gram positive filamentous bacilli in background of acute inflammation on smears. This was confirmed by 16S ribosomal gene sequencing. Prompt identification of N. farcinica is important because of its intrinsic resistance to broad spectrum cephalosporins and high risk of dissemination.
Ronald M Angeles; Rocco P Lasala; Cristina V Fanning
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  36     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-9     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Section of Cytopathology, Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Anti-Infective Agents / administration & dosage,  pharmacology,  therapeutic use
Biopsy, Fine-Needle
Drug Resistance, Multiple, Bacterial
Gentian Violet
Microbial Sensitivity Tests
Nocardia / drug effects,  genetics,  isolation & purification,  physiology*
Nocardia Infections / diagnosis*,  drug therapy,  microbiology*
RNA, Ribosomal, 16S / genetics*
Sequence Analysis, DNA
Skin Diseases, Bacterial / diagnosis*,  drug therapy,  microbiology*,  pathology
Trimethoprim-Sulfamethoxazole Combination / administration & dosage,  pharmacology,  therapeutic use
Reg. No./Substance:
0/Anti-Infective Agents; 0/Gram's stain; 0/Phenazines; 0/RNA, Ribosomal, 16S; 548-62-9/Gentian Violet; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

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