Document Detail


Disseminated microvascular pulmonary tumor cell embolism: a rare cause of fulminant pulmonary hypertension.
MedLine Citation:
PMID:  15591717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Disseminated pulmonary tumor embolization is a rare cause of pulmonary hypertension and is often diagnosed only after the patient has died. CASE REPORT: We report on a 41-year-old male who was admitted because of severe dyspnea and tachycardia. Contrast enhanced spiral computed tomography did neither establish pulmonary thromboembolism nor pulmonary metastasis. Right heart catheterization revealed severe pulmonary hypertension (pulmonary vascular resistance (PVR) 678 dyn x sec x cm(-5)). PVR did not respond to therapy with intravenous nitrate or inhaled iloprost in this critically ill patient. 2 days after admission, the patient died because of refractory right heart failure. Autopsy revealed microscopic pulmonary tumor embolism due to a metastasizing adenocarcinoma of the pancreas. CONCLUSION: Disseminated tumor cell embolism should be considered as a rare differential diagnosis in patients with refractory pulmonary hypertension.
Authors:
S Steiner; G Plehn; P Reinecke; M Cohnen; B Schwartzkopff; M G Hennersdorf; B E Strauer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Onkologie     Volume:  27     ISSN:  0378-584X     ISO Abbreviation:  Onkologie     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-02-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  566-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Germany. Steinest@uni-duesseldorf.de
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications,  diagnosis,  secondary
Adult
Diagnosis, Differential
Disseminated Intravascular Coagulation / complications,  diagnosis
Humans
Hypertension, Pulmonary / classification,  diagnosis*,  etiology*
Lung Neoplasms / complications,  diagnosis,  secondary*
Male
Neoplastic Cells, Circulating / pathology*
Pancreatic Neoplasms / complications*,  diagnosis
Pulmonary Embolism / complications*,  diagnosis*
Rare Diseases
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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