Document Detail

Disseminated intravascular coagulation in a patient with acute myeloid leukemia. Ultrastructural evidence of hypercoagulation in bone marrow.
MedLine Citation:
PMID:  8322704     Owner:  NLM     Status:  MEDLINE    
The bone marrow of a 53-year-old woman with acute myeloid leukemia (AML) with disseminated intravascular coagulation was investigated by transmission electron microscopy. The patient had a preceding granulocytic sarcoma, and subclinical disseminated intravascular coagulation occurred concomitantly with the development of AML. Ultrastructural findings of the bone marrow at the onset of AML revealed the following: (1) The cytoplasm of the leukemic cells showed frequent fragmentation, resulting in the formation of abundant cytoplasmic fragments. (2) These cytoplasmic fragments were surrounded by abundant fibrin fibers, forming the fibrin-cytoplasmic fragment complex (FCF complex). (3) Slight fibrin deposition was seen around the leukemic cells and in the intercellular space of the bone marrow. Fibrin deposition in the bone marrow is thought to represent morphologic evidence of disseminated intravascular coagulation. The damage on the leukemic cell surface due to the cytoplasmic fragmentation seems to be closely related to the development of disseminated intravascular coagulation.
N Takemori; K Hirai; R Onodera; H Uenishi; N Saito; Y Takasugi; M Namiki; S Muraoka
Related Documents :
20858854 - Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering a...
10676644 - Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex...
2615464 - Detection of brdu in the regenerating bone marrow cells of a patient with aml.
10389934 - Expression of the 67-kda laminin receptor in acute myeloid leukemia cells mediates adhe...
15905544 - Il-3 induces inhibitor of dna-binding protein-1 in hemopoietic progenitor cells and pro...
10819494 - Autografting with peripheral blood cd34-positive cells following high-dose chemotherapy...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  99     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-30     Completed Date:  1993-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  695-701     Citation Subset:  AIM; IM    
Third Department of Internal Medicine, Asahikawa Medical College, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Antigens, CD / analysis
Blood Coagulation Tests
Bone Marrow / pathology,  ultrastructure*
Cytoplasm / ultrastructure
Disseminated Intravascular Coagulation / blood,  complications,  pathology*
Fibrin / analysis
Fibrinogen / analysis
Leukemia, Myeloid / blood,  complications,  pathology*
Middle Aged
Reg. No./Substance:
0/Antigens, CD; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Failure of the International Normalized Ratio to generate consistent results within a local medical ...
Next Document:  Comparison of nuclear grade and DNA cytometry in breast carcinoma aspirates to histologic grade in e...