Document Detail

Disseminated intravascular coagulation developed in hyperbaric oxygen.
MedLine Citation:
PMID:  655996     Owner:  NLM     Status:  MEDLINE    
Male rats of 260 g were exposed to hyperbaric conditions of oxygen with different partial pressures and the changes of the haemostasis were studied. In 100% oxygen at 2 ATA, the animals died within 48 h. In 100% oxygen at 1 ATA, death occurred only after 3 d; however, in 24-48 h there developed disseminated intravascular coagulation (DIC). At the same time uncompensated acidosis of 7.34 +/- 0.02 was measured. Perivascular bleeding could be histologically demonstrated in different organs. The mixture of 60% oxygen and 40% nitrogen caused only a minimal DIC while a mixture of 40% oxygen and 60% nitrogen caused no changes in the haemostasis. Volunteer young males exposed to the mixture of 60% oxygen and 40% nitrogen, developed the beginning symptoms of DIC, which made it necessary to stop the experiments.
L A Pálos; N A Agadjanjan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  49     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  722-3     Citation Subset:  IM; S    
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MeSH Terms
Atmospheric Pressure*
Disseminated Intravascular Coagulation / etiology*
Reg. No./Substance:

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