| Disseminated intravascular coagulation: current concepts. | |
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MedLine Citation:
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PMID: 18716745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disseminated intravascular coagulation (DIC) is an acquired disorder in which normal hemostatic balance is disturbed. There is excessive thrombin formation leading to fibrin deposition in microcirculation and consequent ischemic organ damage. The etiology is multifactorial. A number of medical, surgical, oncological and obstetrical conditions can cause DIC. The diagnosis is essentially clinical supported by laboratory parameters and a scoring system based on these. The mainstay of treatment is correction of underlying cause and hemostatic support with replacement of coagulation factors. The role of heparin therapy and other therapeutic options including activated protein C, antithrombin III etc. have also been discussed. |
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Authors:
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R Kumar; V Gupta |
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Publication Detail:
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Type: Journal Article Date: 2008-08-21 |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 75 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-12-10 Revised Date: 2009-07-15 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 733-8 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology/Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada, R3E, OVN. rajatkr@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Antithrombin III / therapeutic use Blood Component Transfusion Chronic Disease Disseminated Intravascular Coagulation / diagnosis*, etiology, physiopathology, therapy* Heparin / therapeutic use Humans Lipoproteins / therapeutic use Protease Inhibitors / therapeutic use Protein C / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Protease Inhibitors; 0/Protein C; 0/lipoprotein-associated coagulation inhibitor; 9000-94-6/Antithrombin III; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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