Document Detail

Disseminated intravascular coagulation as clinical manifestation of colorectal cancer: a case report and review of the literature.
MedLine Citation:
PMID:  24829174     Owner:  NLM     Status:  In-Data-Review    
We describe the case of a 65-year-old woman, known with ulcerative colitis, who presented with progressive headaches, haematomas and rectal bleeding which turned out to be the initial manifestation of disseminated intravascular coagulation (DIC) associated with colorectal cancer. The presentation posed as a general medicine case but turned out to be a rare oncological complication. The patient revealed possible carcinocythaemia and bone marrow infiltration with signet ring-like cells, as indicators of advanced adenocarcinoma. Treatment of the underlying disease resolved the DIC and contributed to prolonged survival. Subsequently, we reviewed the English literature since 1990 on similar cases and demonstrated that this association is extremely rare and is associated with a poor prognosis. Prompt recognition and treatment of the underlying disease is confirmed to be of utmost importance to prolong (progression-free) survival.
C C van Bunderen; V A de Weger; A Griffioen-Keijzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  72     ISSN:  1872-9061     ISO Abbreviation:  Neth J Med     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-05-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  186-9     Citation Subset:  IM    
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