| Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 7978059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We report a case of infection-associated hemophagocytic syndrome in the setting of disseminated histoplasmosis. PATIENTS AND METHODS: A 6-year-old boy with chronic mucocutaneous candidiasis developed a fulminant hemophagocytic syndrome. Evaluation for an infectious cause included bacterial, mycobacterial, viral, and fungal cultures, serological assessment, and histological examination of bone marrow and bronchoalveolar lavage fluid. RESULTS: Culture of bone marrow aspirate, blood, and bronchoalveolar lavage showed disseminated histoplasmosis as the cause for this patient's hemophagocytic syndrome. The patient was treated with amphotericin B with complete resolution of his hemophagocytic syndrome. CONCLUSIONS: Disseminated histoplasmosis is another cause of IAHS in children with an underlying immunodeficiency. Diagnostic difficulties associated with the hemophagocytic syndromes of childhood are discussed. |
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Authors:
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F G Keller; J Kurtzberg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of pediatric hematology/oncology Volume: 16 ISSN: 0192-8562 ISO Abbreviation: Am J Pediatr Hematol Oncol Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-20 Completed Date: 1994-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7908071 Medline TA: Am J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 368-71 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow
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physiopathology Child Histiocytosis, Non-Langerhans-Cell / microbiology*, physiopathology Histoplasmosis / complications*, physiopathology Humans Male Phagocytosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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