Document Detail

Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.
MedLine Citation:
PMID:  7978059     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We report a case of infection-associated hemophagocytic syndrome in the setting of disseminated histoplasmosis. PATIENTS AND METHODS: A 6-year-old boy with chronic mucocutaneous candidiasis developed a fulminant hemophagocytic syndrome. Evaluation for an infectious cause included bacterial, mycobacterial, viral, and fungal cultures, serological assessment, and histological examination of bone marrow and bronchoalveolar lavage fluid. RESULTS: Culture of bone marrow aspirate, blood, and bronchoalveolar lavage showed disseminated histoplasmosis as the cause for this patient's hemophagocytic syndrome. The patient was treated with amphotericin B with complete resolution of his hemophagocytic syndrome. CONCLUSIONS: Disseminated histoplasmosis is another cause of IAHS in children with an underlying immunodeficiency. Diagnostic difficulties associated with the hemophagocytic syndromes of childhood are discussed.
F G Keller; J Kurtzberg
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of pediatric hematology/oncology     Volume:  16     ISSN:  0192-8562     ISO Abbreviation:  Am J Pediatr Hematol Oncol     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7908071     Medline TA:  Am J Pediatr Hematol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  368-71     Citation Subset:  IM    
Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506.
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MeSH Terms
Bone Marrow / physiopathology
Histiocytosis, Non-Langerhans-Cell / microbiology*,  physiopathology
Histoplasmosis / complications*,  physiopathology

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