Document Detail

Disseminated coccidioidomycosis in pregnancy.
MedLine Citation:
PMID:  17425401     Owner:  NLM     Status:  MEDLINE    
Coccidioidomycosis is a fungal infection contracted through the inhalation of airborne spores, which are most frequently present in desert areas of the southwestern United States and Mexico. Primary immune response to infection is by T(H)1, a subset of helper T cells. Although pulmonary symptoms are most common, hematogenous systemic spread can also occur. Pregnancy is a well-noted risk factor for disseminated Coccidioides infection. The objective of this review is to provide an overview of coccidioidomycosis and to review immunologic and hormonal factors that increase risk of dissemination in pregnancy. Dissemination may occur more frequently in pregnant patients than in nonpregnant women because of shifts in T-cell immunity, changes in cytokine production, and increased hormone levels. There is disagreement regarding the precise incidence of systemic spread in pregnancy, but most sources agree that risk is substantially increased and vigilance must be high in patients with exposures in endemic areas.
Jody E Hooper; Qun Lu; Samuel H Pepkowitz
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  131     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  652-5     Citation Subset:  AIM; IM    
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
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MeSH Terms
Coccidioidomycosis / diagnosis*,  immunology*,  therapy,  transmission
Infant, Newborn
Pregnancy Complications, Infectious / diagnosis*,  immunology*,  therapy

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