Document Detail

Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight.
MedLine Citation:
PMID:  22333013     Owner:  NLM     Status:  In-Data-Review    
Systemic fungal infections have high morbidity and mortality rates in neonates, especially neonates with an extremely low birth weight (ELBW). Here, we describe a 21-day-old ELBW female infant with an amphotericin B-unresponsive congenital Candida albicans infection that was treated with caspofungin. Blood sterilization was performed during the first episode, but a second episode of candidemia occurred after the discontinuation of caspofungin. Blood sterilization was again performed during the second round of caspofungin treatment, but fungal endocarditis and renal fungal balls still developed during the second episode. Caspofungin can be considered for invasive candidiasis in premature infants, especially in life-threatening situations. As for the focal lesions, more aggressive treatments other than just parenteral antibiotics should be considered. The literature regarding caspofungin therapy for neonatal candidiasis is also reviewed.
Meng-Ju Li; Po-Ren Hsueh; Chun-Yi Lu; Hung-Chieh Chou; Ping-Ing Lee; Luan-Yin Chang; Li-Min Huang
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Publication Detail:
Type:  Journal Article     Date:  2012-02-02
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  111     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
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