Document Detail

Disseminated blastomycosis in a pregnant woman successfully treated with amphotericin-B. A case report.
MedLine Citation:
PMID:  3385706     Owner:  NLM     Status:  MEDLINE    
An 18-year-old woman developed disseminated blastomycosis in the 30th week of pregnancy. She was treated with amphotericin-B. Simultaneous maternal-infant blood levels at birth were 1.9 and 1.3 micrograms/mL, respectively. The amphotericin-B level in the amniotic fluid was 0.3 microgram/mL at delivery. The infant was normal and without ill effects from either the blastomycosis or the amphotericin-B. The skin lesions and pulmonary infiltrates in the mother improved rapidly, without unexpected side effects from the therapy. The limited experience with amphotericin-B indicates that it is both well tolerated and effective in this clinical situation.
H Hager; S I Welt; J P Cardasis; S Alvarez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  33     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-08-01     Completed Date:  1988-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-8     Citation Subset:  IM    
Department of Internal Medicine, Quillen-Dishner College of Medicine, Johnson City, Tennessee.
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MeSH Terms
Amphotericin B / pharmacokinetics,  therapeutic use*
Blastomycosis / drug therapy*
Maternal-Fetal Exchange
Pregnancy Complications, Infectious / drug therapy*
Reg. No./Substance:
1397-89-3/Amphotericin B

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