Document Detail


Disseminated bacille Calmette-Guérin infection in an infant with a novel deletion in the interferon-gamma receptor gene.
MedLine Citation:
PMID:  10949334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six weeks after receiving BCG vaccination, a Canadian aboriginal infant presented with suspected sepsis, lymphadenopathy and hepatosplenomegaly. Lymph node biopsy revealed macrophages filled with acid-fast bacilli. Mycobacterium bovis was cultured from tissue specimens and there was evidence of concomitant cytomegalovirus disease. The infant died of disseminated BCG infection. A novel deletion at nucleotide 165 in the interferon-gamma receptor (IFN-gammaR1) was identified. The incidence of this mutation in the aboriginal population and the impact on the heterozygous state are unknown.
Authors:
J A Cunningham; J D Kellner; P J Bridge; C L Trevenen; D R Mcleod; H D Davies
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  4     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-02-08     Completed Date:  2001-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  791-4     Citation Subset:  IM    
Affiliation:
Division of Infectious Diseases, Foothills Hospital.
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MeSH Terms
Descriptor/Qualifier:
BCG Vaccine / adverse effects*
Biopsy
Fatal Outcome
Gene Deletion*
Humans
Immunocompromised Host
Immunoglobulin G
Immunoglobulin M
Infant
Interferon-gamma / genetics*
Lymph Nodes / pathology
Male
Mycobacterium bovis / isolation & purification
Receptors, Interferon / genetics*
Tuberculosis / etiology*,  microbiology
Chemical
Reg. No./Substance:
0/BCG Vaccine; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Receptors, Interferon; 0/interferon gamma receptor; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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