| Disseminated autoimmune disease during levamisole treatment of nephrotic syndrome. | |
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MedLine Citation:
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PMID: 10460511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Side effects such as cutaneous vasculitis, which occur during prolonged levamisole treatment, may discourage the utilization of the drug in relapsing nephrotic syndrome. We describe a child who developed disseminated vasculitis during prolonged treatment with levamisole. The acute phase was characterized by hepatosplenomegaly, hemolytic anemia, IgM anticardiolipin and p-antineutrophil cytoplasmic antibodies. One month after withdrawal of therapy all symptoms had disappeared and tests normalized. This case report, together with other reports on cutaneous vasculitis, suggest caution and close monitoring during prolonged levamisole therapy. |
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Authors:
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G Barbano; F Ginevri; G M Ghiggeri; R Gusmano |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 13 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-28 Completed Date: 1999-09-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 602-3 Citation Subset: IM |
Affiliation:
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Department of Nephrology, G. Gaslini Children's Hospital, Largo G. Gaslini, 5, I-16148 Genoa, Italy. Labnefro@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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adverse effects*,
therapeutic use Autoimmune Diseases / chemically induced* Child, Preschool Humans Levamisole / adverse effects*, therapeutic use Male Nephrotic Syndrome / drug therapy* Vasculitis, Leukocytoclastic, Cutaneous / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 14769-73-4/Levamisole |
| Comments/Corrections | |
Comment In:
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Pediatr Nephrol. 2000 Sep;14(10-11):1057-8
[PMID:
10975325
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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