Document Detail


Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000.
MedLine Citation:
PMID:  11692307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disseminated Mycobacterium avium complex disease remains a substantial cause of morbidity and mortality among patients with acquired immunodeficiency syndrome. From 1985 through 2000, we studied 1458 consecutive patients at Grady Memorial Hospital, Atlanta, with disseminated M. avium complex disease. There was a peak of 198 patients in the 1995, which decreased to 66 patients in 2000. In 1997, significantly more patients than in 1991 or 1994 were female (P<.001) or black (P<.001) and significantly fewer had acquired human immunodeficiency virus through homosexual contact (P<.001). In 1997, 50 (51%) of 99 of patients acquired M. avium complex disease despite receiving antimicrobial prophylaxis, but 32 (89%) of 36 patients did not adhere to the prophylaxis regimen. The median duration of survival of patients in 1991 was 110 days, whereas in 1994 it was 185 days, and in 1997 it was 339 days (P<.001). Prolonged survival was associated with receiving therapy that included clarithromycin and receiving combination antiretroviral therapy that included a protease inhibitor.
Authors:
C R Horsburgh; J Gettings; L N Alexander; J L Lennox
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Publication Detail:
Type:  Journal Article     Date:  2001-10-24
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  33     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1938-43     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. rhorsbu@bu.edu
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections* / complications,  epidemiology,  therapy
Acquired Immunodeficiency Syndrome / complications*,  drug therapy
Adult
Female
Humans
Incidence
Male
Mycobacterium avium-intracellulare Infection* / complications,  epidemiology,  therapy
Risk Factors
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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