| Disseminated intravascular coagulation in obstetric and gynecologic disorders. | |
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MedLine Citation:
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PMID: 20614392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disseminated intravascular coagulation (DIC) is a syndrome characterized by a massive, widespread, and ongoing activation of the coagulation system, secondary to a variety of clinical conditions. Many obstetric complications, such as abruptio placentae, amniotic fluid embolism, endotoxin sepsis, retained dead fetus, post-hemorrhagic shock, hydatidiform mole, and gynecologic malignancies, might trigger DIC. In these gynecologic and obstetric settings, DIC is usually associated with high mortality and morbidity rates. No single laboratory test is sensitive or specific enough to diagnose DIC definitively, but it can be diagnosed by using a combination of multiple clinical and laboratory tests that reflect the pathophysiology of the syndrome. At present, the therapeutical approach to pregnancy- and gynecologic-related DIC comprises the specific and aggressive treatment of the underlying disease, eventually followed by a supportive blood product replacement therapy and restoration of physiological anticoagulant pathways. This article reviews the etiopathogenesis, clinical manifestations, laboratory diagnosis, and therapy of pregnancy- and gynecologic-related DIC. |
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Authors:
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Martina Montagnana; Massimo Franchi; Elisa Danese; Francesca Gotsch; Gian Cesare Guidi |
Publication Detail:
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Type: Journal Article; Review Date: 2010-07-07 |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: 36 ISSN: 1098-9064 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 404-18 Citation Subset: IM |
Copyright Information:
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Copyright Thieme Medical Publishers. |
Affiliation:
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Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, Italy. martina.montagnana@med.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Disseminated Intravascular Coagulation
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blood,
diagnosis,
physiopathology*,
therapy Female Genital Diseases, Female / blood*, diagnosis, physiopathology, therapy Humans Pregnancy Pregnancy Complications, Hematologic / blood*, diagnosis, physiopathology, therapy |
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