Document Detail


Disseminated intravascular coagulation in obstetric and gynecologic disorders.
MedLine Citation:
PMID:  20614392     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disseminated intravascular coagulation (DIC) is a syndrome characterized by a massive, widespread, and ongoing activation of the coagulation system, secondary to a variety of clinical conditions. Many obstetric complications, such as abruptio placentae, amniotic fluid embolism, endotoxin sepsis, retained dead fetus, post-hemorrhagic shock, hydatidiform mole, and gynecologic malignancies, might trigger DIC. In these gynecologic and obstetric settings, DIC is usually associated with high mortality and morbidity rates. No single laboratory test is sensitive or specific enough to diagnose DIC definitively, but it can be diagnosed by using a combination of multiple clinical and laboratory tests that reflect the pathophysiology of the syndrome. At present, the therapeutical approach to pregnancy- and gynecologic-related DIC comprises the specific and aggressive treatment of the underlying disease, eventually followed by a supportive blood product replacement therapy and restoration of physiological anticoagulant pathways. This article reviews the etiopathogenesis, clinical manifestations, laboratory diagnosis, and therapy of pregnancy- and gynecologic-related DIC.
Authors:
Martina Montagnana; Massimo Franchi; Elisa Danese; Francesca Gotsch; Gian Cesare Guidi
Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-07
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  36     ISSN:  1098-9064     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  404-18     Citation Subset:  IM    
Copyright Information:
Copyright Thieme Medical Publishers.
Affiliation:
Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, Italy. martina.montagnana@med.lu.se
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MeSH Terms
Descriptor/Qualifier:
Disseminated Intravascular Coagulation / blood,  diagnosis,  physiopathology*,  therapy
Female
Genital Diseases, Female / blood*,  diagnosis,  physiopathology,  therapy
Humans
Pregnancy
Pregnancy Complications, Hematologic / blood*,  diagnosis,  physiopathology,  therapy

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