Document Detail

Disseminated Bartonella infection following liver transplantation.
MedLine Citation:
PMID:  16827686     Owner:  NLM     Status:  MEDLINE    
Bartonella henselae has not only been identified as the causative agent of cat scratch disease, but it is also associated with other significant infectious syndromes in the immunocompromised population. We describe two cases of B. henselae associated diseases in liver transplant recipients who both had contact with cats. The first recipient developed localized skin manifestation of bacillary angiomatosis in association with granulomatous hepatitis. He tested positive for Immunoglobulin G (IgG) antibodies against B. henselae. The second patient developed axillary lymphadenopathy, with biopsy showing necrotizing granulomatous inflammation and polymerase chain reaction studies were positive for B. henselae DNA. Her serology for bartonellosis showed a fourfold rise in antibody titers during her hospitalization. Both patients responded to treatment with Azithromycin in combination with Doxycycline. These were the only cases within a series of 467 consecutive liver transplants performed in 402 patients performed during a 4-year period. Although bartonellosis is a rare infection in liver transplantation recipients, it should always be included in the differential diagnosis of patients presenting with fever, central nervous system (CNS) symptoms, skin lesions, lymphadenopathy, and hepatitis especially if prior contact with cats is reported.
Hugo Bonatti; Julio Mendez; Ivan Guerrero; Murli Krishna; Jaime Ananda-Michel; Joseph Yao; Jeffery L Steers; Walter Hellinger; Rolland C Dickson; Salvador Alvarez
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  19     ISSN:  0934-0874     ISO Abbreviation:  Transpl. Int.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  683-7     Citation Subset:  IM    
Transplant Center, Mayo Clinic, Jacksonville, FL, USA.
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MeSH Terms
Angiomatosis, Bacillary / diagnosis,  etiology
Antibodies, Bacterial / blood
Bartonella Infections / diagnosis,  etiology*,  microbiology
Bartonella henselae / genetics,  immunology,  isolation & purification
Cat-Scratch Disease / diagnosis,  etiology
Hepatitis A / etiology
Immunocompromised Host
Liver Transplantation / adverse effects*
Middle Aged
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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