Document Detail


Disseminated BCG infection resembling langerhans cell histiocytosis in an infant with severe combined immunodeficiency: a case report.
MedLine Citation:
PMID:  15552821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a very rare congenital immunologic disease, severe combined immunodeficiency syndrome (SCID) in 6-months-old-boy with prolonged mucocutaneous candidiasis, severe anaemia, skin rash similar to the infiltrative eczema of Langerhans cell histiocytosis (LCH) and subcutaneous nodules with histiocytic infiltration. Laboratory findings show profound absence of humoral and cell-mediated immunity. Pathology specimens analysis of subcutaneous nodule revealed numerous S-100 protein and Cd1a negative histiocytes, occupied by BCG intracellular growth. Histopathology and immunohistochemistry confirmed the diagnosis of BCG dissemination. BCG vaccination in infants with SCID can lead to life threatening dissemination, resembling to the infiltrative eczema of LCH and may mislead the clinician.
Authors:
Srdjana Culic; Ivana Kuzmic; Vida Culic; Roko Martinic; Dubravka Kuljis; Ankica Pranic-Kragic; Ksenija Karaman; Stipan Jankovic
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  21     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  563-72     Citation Subset:  IM    
Affiliation:
Clinical Hospital Split, Pediatrics Clinic, Split, Spinciceva, Croatia. srdjana.culic@st.htnet.hr
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MeSH Terms
Descriptor/Qualifier:
BCG Vaccine / adverse effects*
Diagnosis, Differential
Histiocytosis, Langerhans-Cell / diagnosis*
Humans
Infant
Male
Severe Combined Immunodeficiency / complications*
Tuberculosis / diagnosis*,  etiology
Chemical
Reg. No./Substance:
0/BCG Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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