| Dissection of perceptual, motor and autonomic components of brain activity evoked by noxious stimulation. | |
| | |
MedLine Citation:
|
PMID: 20417032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the past two decades, functional brain imaging has considerably advanced our knowledge of cerebral pain processing. However, many important links are still missing in our understanding of brain activity in relation to the regulation of pain-related physiological responses. This fMRI study investigates the cerebral correlates of pain (rating), motor responses (RIII-reflex) and autonomic activity (skin conductance response; SCR) evoked by noxious electrical stimulation. Stimulus intensity was adjusted individually based on the RIII threshold to control for differences in peripheral processes and baseline spinal activation. Covariance analyses were used to reveal individual differences in brain activity uniquely associated with individual differences in pain, RIII and SCR. Shock-evoked activity in cingulate, medial orbitofrontal and parahippocampal regions predicted pain sensitivity. Moreover, lateral orbitofrontal and cingulate areas showed strong positive associations with individual differences in motor reactivity but negative associations with autonomic reactivity. Notably, individual differences in OFC activation was almost fully accounted by the combination of individual measures of autonomic and motor reactivity (R(2)=0.93). Additionally, trial-to-trial fluctuations of RIII-reflex and SCR (within-subjects) were proportional to shock-evoked responses in subgenual cingulate cortex (RIII), anterior insula (SCR) and midcingulate cortex (SCR and RIII). Together, these results confirm that individual differences in perceptual, motor, and autonomic components of pain reflect robust individual differences in brain activity. Furthermore, the brain correlates of trial-to-trial fluctuations in pain responses provide additional evidence for a partial segregation of sub-systems involved more specifically in the ongoing monitoring, and possibly the regulation, of pain-related motor and autonomic responses. |
| | |
Authors:
|
M Piché; M Arsenault; P Rainville |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-22 |
Journal Detail:
|
Title: Pain Volume: 149 ISSN: 1872-6623 ISO Abbreviation: Pain Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-18 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 453-62 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Université de Montréal, Montréal, Que., Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Autonomic Nervous System / physiology* Brain / anatomy & histology, physiology* Brain Mapping / methods Electric Stimulation / adverse effects* Female Humans Magnetic Resonance Imaging Male Motor Cortex / physiology* Pain / physiopathology* Pain Measurement Perception / physiology* Reflex / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
//Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of different forms of acidities on soil microbiological properties and enzyme activities a...
Next Document: Optimization of pulsed laser atom probe (PLAP) for the analysis of nanocomposite Ti-Si-N films.