Document Detail

Dissecting teleost B cell differentiation using transcription factors.
MedLine Citation:
PMID:  21251922     Owner:  NLM     Status:  MEDLINE    
B cell developmental pathways in teleost fishes are poorly understood. In the absence of serological reagents, an alternative approach to dissecting teleost B cell development is to use transcription factors that are differentially expressed during B cell development. This review discusses the structure and function of six transcription factors that play essential roles during teleost B cell development: Ikaros, E2A, EBF, Pax5, Blimp1, and XbpI. Research on alternative splicing of both the Ikaros and Pax5 genes in rainbow trout is presented, including their functional significance. An application is discussed that should aid in elucidating teleost B cell development and activation, by using transcription factors as developmental markers in flow cytometric analysis. Possible future studies in teleost B cell development are suggested in the context of gene regulation. Lastly, broader impacts and practical applications are discussed.
Patty Zwollo
Publication Detail:
Type:  Journal Article; Review     Date:  2011-01-17
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  35     ISSN:  1879-0089     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-06-28     Completed Date:  2011-11-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  898-905     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
The College of William and Mary, Department of Biology, Williamsburg, VA 23187, USA.
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MeSH Terms
Alternative Splicing / immunology
B-Lymphocytes / cytology,  immunology,  metabolism*
Cell Differentiation / genetics,  immunology
Cell Separation
Fishes / immunology
Flow Cytometry
Gene Expression Regulation, Developmental / immunology
Lymphocyte Activation / genetics
Transcription Factors / immunology*
Grant Support
R15 AI070249-01/AI/NIAID NIH HHS
Reg. No./Substance:
0/Transcription Factors

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