Document Detail

Dissecting the role of infections in atopic dermatitis.
MedLine Citation:
PMID:  16648910     Owner:  NLM     Status:  MEDLINE    
In patients with atopic dermatitis the skin is highly susceptible to infection by bacteria, fungi and viruses. Increasing knowledge about the complex immune network that regulates anti-microbial responses has helped to dissect further the role of infections in atopic dermatitis. Conserved patterns of microbes are recognized by the innate immune system, which mediates microbicidal activity, either directly or through inflammatory responses. New evidence suggests that components of the innate immune system, such as anti-microbial peptides, humoural lectins, nucleotide-binding oligomerization domain-containing (NOD) proteins, and Toll-like receptors not only protect from microbial invasion, but contribute to skin inflammation in atopic dermatitis. In addition, atopic patients tend to develop Th2-dominated immune responses that weaken anti-microbial immunity. This impairment of an appropriate anti-microbial defence compounded by amplified microbe-driven innate and adaptive immune responses leads to the vicious circle of skin inflammation. New microbial management in atopic dermatitis will foster a well-balanced microbial flora, which establishes natural defence mechanisms to maintain immuno-surveillance of the skin. In addition to anti-microbial therapies, other innate immune stimuli may suppress pro-inflammatory signals and help to break the vicious circle of cutaneous inflammation. To elucidate further these different interactions of the skin immune system and microbes in atopic dermatitis, clinical studies and further efforts in basic research are needed.
Tilo Biedermann
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  86     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-09-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  99-109     Citation Subset:  IM    
Department of Dermatology, Eberhard Karls University Tuebingen, Germany.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Antimicrobial Cationic Peptides / immunology
Bacterial Infections / drug therapy,  immunology*
Dermatitis, Atopic / drug therapy,  immunology*
Disease Susceptibility
Immunity, Innate
Th2 Cells / immunology
Toll-Like Receptors / immunology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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