| Dissecting the immune response to the entomopathogen Photorhabdus. | |
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MedLine Citation:
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PMID: 21035345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival. Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity. During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host. Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila. Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens. |
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Authors:
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Ioannis Eleftherianos; Richard H ffrench-Constant; David J Clarke; Andrea J Dowling; Stuart E Reynolds |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-28 |
Journal Detail:
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Title: Trends in microbiology Volume: 18 ISSN: 1878-4380 ISO Abbreviation: Trends Microbiol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 552-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA. ioannise@gwu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Immune Evasion Insects / immunology, microbiology* Nematoda / metabolism Phagocytosis Photorhabdus / pathogenicity, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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