| Dissecting the immune cell mayhem that drives lupus pathogenesis. | |
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MedLine Citation:
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PMID: 21389262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The autoimmune disease systemic lupus erythematosus (SLE) results from an inability of the immune system to discriminate between certain self-antigens and foreign ones. The most common treatment of SLE involves the use of immunosuppressive drugs to reduce inflammation, but these therapies have serious side effects. Three recent papers in Science Translational Medicine redirect focus on neutrophils, platelets, and interferon-α in the pathogenesis of SLE and reinforce the notion that researchers should seek to discover and devise combination therapies that target these processes. |
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Authors:
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Joseph E Craft |
Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science translational medicine Volume: 3 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-10 Completed Date: 2011-07-06 Revised Date: 2012-03-16 |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 73ps9 Citation Subset: IM |
Affiliation:
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Section of Rheumatology, Department of Internal Medicine, and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. joseph.craft@yale.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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biosynthesis Blood Platelets / immunology Humans Interferon-alpha / biosynthesis Lupus Erythematosus, Systemic / blood, etiology*, immunology*, therapy Models, Immunological Neutrophils / immunology Platelet Activation |
| Grant Support | |
ID/Acronym/Agency:
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5 R01 AI075157/AI/NIAID NIH HHS; P30 AR053495/AR/NIAMS NIH HHS; R01 AI075157-05/AI/NIAID NIH HHS; R01 AR040072-23/AR/NIAMS NIH HHS; R01 AR40072/AR/NIAMS NIH HHS; R01 AR44076/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Interferon-alpha |
| Comments/Corrections | |
Comment On:
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Sci Transl Med. 2011 Mar 9;3(73):73ra20
[PMID:
21389264
]
Sci Transl Med. 2010 Sep 1;2(47):47ra63 [PMID: 20811042 ] Sci Transl Med. 2011 Mar 9;3(73):73ra19 [PMID: 21389263 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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