Document Detail

Dissecting how receptor tyrosine kinases modulate G protein-coupled receptor function.
MedLine Citation:
PMID:  20828551     Owner:  NLM     Status:  MEDLINE    
Receptor tyrosine kinases and G protein-coupled receptors modulate physiological processes and are also involved in the pathogenesis of some diseases. These receptors have intense bidirectional crosstalks leading to interactions in their signaling pathways and also modulation of the receptors themselves. In some cases, the receptor tyrosine kinases phosphorylate G protein-coupled receptors whereas in others phosphoinositide 3-kinase, protein kinase B and protein kinase C are key elements in these crosstalks. Two paracrine/ autocrine processes also participate, i.e., epidermal growth factor transactivation and sphingosine 1-phosphate generation and signaling. G proteins seem to mediate actions of receptor tyrosine kinases, but how this takes place is far from completely understood; some models are presented. Recent data indicate that the mitogen activated protein kinase cascade also mediate crosstalks. In the present perspective these processes are outlined using information from receptors that have been intensively studied, and important gaps in our knowledge are indicated.
J Adolfo García-Sáinz; M Teresa Romero-Ávila; Luz del Carmen Medina
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-07
Journal Detail:
Title:  European journal of pharmacology     Volume:  648     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, México D.F. 04510.
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MeSH Terms
GTP-Binding Proteins / metabolism
MAP Kinase Signaling System
Phosphatidylinositol 3-Kinases / metabolism
Protein-Serine-Threonine Kinases / metabolism
Receptor Protein-Tyrosine Kinases / chemistry,  metabolism*
Receptors, G-Protein-Coupled / chemistry,  metabolism*
Reg. No./Substance:
0/Receptors, G-Protein-Coupled; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC Protein-Tyrosine Kinases; EC Kinases; EC 3.6.1.-/GTP-Binding Proteins

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