| Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation. | |
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MedLine Citation:
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PMID: 22491324 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Feeding behaviour is modulated by both environmental cues and internal physiological states. Appetite is commonly boosted by the pleasant smell (or appearance) of food and destroyed by a bad taste. In reality, animals sense multiple environmental cues at the same time and it is not clear how these sensory inputs are integrated and a decision is made to regulate feeding behaviour accordingly. Here we show that feeding behaviour in Caenorhabditis elegans can be either facilitated by attractive odours or suppressed by repellents. By identifying mutants that are defective for sensory-mediated feeding regulation, we dissected a central flip-flop circuit that integrates two contradictory sensory inputs and generates bistable hormone output to regulate feeding behaviour. As feeding regulation is fundamental to animal survival, we speculate that the basic organizational logic identified here in C. elegans is likely convergent throughout different phyla. |
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Authors:
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Zhaoyu Li; Yidong Li; Yalan Yi; Wenming Huang; Song Yang; Weipin Niu; Li Zhang; Zijing Xu; Anlian Qu; Zhengxing Wu; Tao Xu |
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Publication Detail:
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Type: Journal Article Date: 2012-04-10 |
Journal Detail:
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Title: Nature communications Volume: 3 ISSN: 2041-1723 ISO Abbreviation: Nat Commun Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101528555 Medline TA: Nat Commun Country: England |
Other Details:
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Languages: eng Pagination: 776 Citation Subset: IM |
Affiliation:
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1] College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. [2]. |
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