Document Detail

Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation.
MedLine Citation:
PMID:  22491324     Owner:  NLM     Status:  In-Data-Review    
Feeding behaviour is modulated by both environmental cues and internal physiological states. Appetite is commonly boosted by the pleasant smell (or appearance) of food and destroyed by a bad taste. In reality, animals sense multiple environmental cues at the same time and it is not clear how these sensory inputs are integrated and a decision is made to regulate feeding behaviour accordingly. Here we show that feeding behaviour in Caenorhabditis elegans can be either facilitated by attractive odours or suppressed by repellents. By identifying mutants that are defective for sensory-mediated feeding regulation, we dissected a central flip-flop circuit that integrates two contradictory sensory inputs and generates bistable hormone output to regulate feeding behaviour. As feeding regulation is fundamental to animal survival, we speculate that the basic organizational logic identified here in C. elegans is likely convergent throughout different phyla.
Zhaoyu Li; Yidong Li; Yalan Yi; Wenming Huang; Song Yang; Weipin Niu; Li Zhang; Zijing Xu; Anlian Qu; Zhengxing Wu; Tao Xu
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Publication Detail:
Type:  Journal Article     Date:  2012-04-10
Journal Detail:
Title:  Nature communications     Volume:  3     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  776     Citation Subset:  IM    
1] College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. [2].
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