Document Detail


Disruptions of the mother-infant relationship and stress-related behaviours: altered corticosterone secretion does not explain everything.
MedLine Citation:
PMID:  19751762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothalamic-pituitary-adrenal (HPA) axis is the main neuroendocrine system of response to stress, and an imbalance of this system's activity is believed to be at the core of numerous psychiatric pathologies. During the neonatal period, the glucocorticoid response to stress is maintained at low levels by specific maternal behaviours, which is essential for proper brain development. Effective evaluation of the impact of increased secretion of corticosterone during an essentially anabolic developmental period on adulthood behaviour involved separation of the neonate from its mother for periods ranging from 3 to 24h. It has been shown that disinhibition of the stress response is achieved by such procedures. The pioneering studies by Seymour Levine set the stage for a prolific and promising field of study that may help neuroscientists unveil the neurobiological underpinnings of stress-related disorders. Based on a series of studies, we propose that maternal separation and maternal deprivation change stress-related behaviours, but that corticosterone seem to be only partially involved in these changes in adulthood. It appears that extra-hypothalamic corticotrophin-releasing factor and neurotransmitter systems may be the primary mediators of these behavioural outcomes.
Authors:
Claudia B Faturi; Paula A Tiba; Suzi E Kawakami; Bruna Catallani; Marieke Kerstens; Deborah Suchecki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-12
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  34     ISSN:  1873-7528     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-34     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
suchecki@psicobio.epm.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiopathology
Corticosterone / secretion*
Female
Humans
Maternal Deprivation*
Mother-Child Relations
Stress, Psychological / physiopathology*
Chemical
Reg. No./Substance:
50-22-6/Corticosterone

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