| Disruption of type 5 adenylyl cyclase negates the developmental increase in Galphaolf expression in the striatum. | |
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MedLine Citation:
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PMID: 15094058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The two stimulatory G protein alpha subunits, Galphas and Galphaolf, activate adenylyl cyclase in a similar way. We examined whether type 5 adenylyl cyclase knockout, the major striatal isoform, can differentially and/or developmentally change the expression of these G proteins in the striatum. Galphas and Galphaolf expressions at birth were unaffected in knockouts, which, however, demonstrated a blunted developmental increase in Galphaolf, but not Galphas. Adenylyl cyclase activity was unaffected at birth, but subsequently became lower in knockouts. These findings suggest that type 5 adenylyl cyclase does not contribute to striatal cAMP signaling at birth. However, it may play an important role in developmental changes in the expression of Galphaolf, but not Galphas. |
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Authors:
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Tamio Iwamoto; Kousaku Iwatsubo; Satoshi Okumura; Yoko Hashimoto; Takashi Tsunematsu; Yoshiyuki Toya; Denis Hervé; Satoshi Umemura; Yoshihiro Ishikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: FEBS letters Volume: 564 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-06-03 Revised Date: 2010-10-13 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Departments of Physiology and Medicine, Yokohama City University School of Medicine, Yokohama 234-0002, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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genetics,
physiology* Age Factors Animals Corpus Striatum / metabolism* GTP-Binding Protein alpha Subunits / biosynthesis Gene Expression Regulation, Developmental* Heterotrimeric GTP-Binding Proteins / biosynthesis* Isoenzymes / genetics, physiology* Mice Mice, Knockout Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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GM067773/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/GTP-Binding Protein alpha Subunits; 0/Isoenzymes; 0/olfactory G protein subunit alpha olf; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins; EC 4.6.1.1/Adenylate Cyclase; EC 4.6.1.1/adenylyl cyclase type V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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