Document Detail


Disruption of male sexual behavior in rats by tetrahydrofurandiols (THF-diols).
MedLine Citation:
PMID:  15927221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mitogenic agent that disrupts male and female sexual behavior has been isolated from corncob bedding. The disrupting activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl groups (THF-diols) that include 9, (12)-oxy-10, 13-dihydroxtstearic acid and 10, (13)-oxy-9, 12-dihydroxystearic acid. We examined the effects of exposure of male rats to THF-diols in drinking water on several parameters of male sexual behavior. THF-diols disrupt sexual behavior in male rats by reducing mounting and intromission frequencies. The mount, intromission and ejaculatory latencies are enhanced while the ejaculatory responses are diminished. These findings suggest that the THF-diols modulate hypothalamo-pituitary axis to regulate steroid hormone-dependent male sexual behavior.
Authors:
Shaila K Mani; Andrea M Reyna; Mary A Alejandro; Jan Crowley; Barry M Markaverich
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Steroids     Volume:  70     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  750-4     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Furans / chemistry,  pharmacology*
Housing, Animal
Hydroxylation
Linoleic Acids / pharmacology*
Male
Phytoestrogens / adverse effects,  pharmacology
Rats
Rats, Sprague-Dawley
Sexual Behavior, Animal / drug effects*
Zea mays
Grant Support
ID/Acronym/Agency:
CA-35480/CA/NCI NIH HHS; ES09964/ES/NIEHS NIH HHS; MH 57442/MH/NIMH NIH HHS; MH 63954/MH/NIMH NIH HHS; P41-RR-00954/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Furans; 0/Linoleic Acids; 0/Phytoestrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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