| Disruption of latent inhibition by acute administration of low doses of amphetamine. | |
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MedLine Citation:
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PMID: 3227035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the latent inhibition (LI) paradigm, nonreinforced preexposure to a stimulus retards subsequent conditioning to that stimulus. Three experiments investigated the effects of acute amphetamine administration on LI in rats. Experiments 1 and 3 used a conditioned emotional response (CER) procedure and Experiment 2 used two-way active avoidance procedure. Experiments 1 and 2 showed that, in both the CER and avoidance procedures, 1.5 mg/kg dl-amphetamine administered either in the preexposure or the conditioning stage alone did not disrupt LI. In contrast, amphetamine administered in both of the stages abolished LI. Experiment 3 showed that the abolition of LI was obtained when the preexposure and conditioning were given 24 hr apart but not when the two stages were given in one session. |
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Authors:
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I Weiner; R E Lubow; J Feldon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 30 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1989-04-04 Completed Date: 1989-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 871-8 Citation Subset: IM |
Affiliation:
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Department of Psychology, Tel-Aviv University, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avoidance Learning / drug effects* Conditioning, Operant / drug effects* Dextroamphetamine / administration & dosage, pharmacology* Drug Administration Schedule Male Rats Rats, Inbred Strains Reference Values |
| Chemical | |
Reg. No./Substance:
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51-64-9/Dextroamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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