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Disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes.
MedLine Citation:
PMID:  23349494     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Patients with type 2 diabetes often show slowing of information processing. Disruptions in the brain white matter network, possibly secondary to vascular damage, may underlie these cognitive disturbances. The present study reconstructed the white matter network of 55 nondemented individuals with type 2 diabetes (mean age 71±4y) and 50 age-, sex- and education-matched controls using diffusion MRI based fiber tractography. Graph theoretical analysis was then applied to quantify the efficiency of these networks. Patients with type 2 diabetes showed alterations in local and global network properties compared to controls (p<0.05). These structural network abnormalities were related to slowing of information processing speed in patients. This relation was partly independent of cerebrovascular lesion load. This study shows that the approach of characterizing the brain as a network using diffusion MRI and graph theory can provide new insights into how abnormalities in the white matter affect cognitive function in patients with diabetes.
Authors:
Yael D Reijmer; Alexander Leemans; Manon Brundel; L Jaap Kappelle; Geert Jan Biessels
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Diabetes     Volume:  -     ISSN:  1939-327X     ISO Abbreviation:  Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University Medical Center Utrecht, Neurology, Heidelberglaan 100, Utrecht, Utrecht, Netherlands.
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